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Prasad Cosmetic Surgery

Posts tagged: PRP

New Technique Holds Promise for Hair Growth

Hair cloning continues to evade medical research by the limitations of the growth of specific cells called dermal papilla cells.When human dermal papilla cells are grown in culture, they lose the ability to grow hair.

The New York Times published an article describing the recent experience of researcher Angela Christiano and  researchers from Durham University in Britain.

They were able to grow dermal papilla cells in a new way.

Essentially they were able to grow dermal papilla cells by inverting the container which the cells would be typically grown in and were able to observe growth that could not be achieved before. It appeared that three dimensional contact between the cells resulted in the needed signals to begin hair growth.

This is another piece of a  large and complex puzzle on how hair grows. The Hair Regeneration System reflects how I have integrated some of the recent studies on the behavior of dermal papilla cells. Cells and signals which are critical to hair growth appears to be what we are restoring with the wound healing technology of ECM (extracellular matrix) by ACell and PRP (platelet rich plasma). Hopefully this research will reveal more specific factors which can be applied clinically in the future.

 

Amiya Prasad, M.D.

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New discovery brings hope for balding men

Based on the headline and worldwide attention of this recent study Dr. Prasad felt compelled to comment and clarify:


In reviewing the article below and associating it with Dr. Cotsarelis’s prior studies and those out of Yale University in Sept. 2011, it seems clear that the increase in Prostaglandin D2 Synthase occurs after the Stem Cells in the fatty layer of the scalp become faulty and stop producing the active Progenitor Cells necessary to protect the genetically sensitive hairs from DHT in the scalp.

Yes one can try to decrease the PD2 levels to theoretically “save” the hairs once the damage is being done, but it would make more sense to replenish the Progenitor cells first to prevent PD2 from exerting any negative effect (if that is what it is doing). We know from Propecia that decreasing 5DHT can slow down and even reverse hair loss in various cases. We now also know that Progenitor Cells act in both men and women (much like Estrogen in young women with genetic hair loss) to protect the hairs from miniaturizing. We have seen excellent results from the combination of ACell/Enhanced PRP which we employ in the Hair Rescue System to stop and often reverse hair loss. This is and should remain the first line of defense rather than damage control–the Hair Rescue results are exciting both in genetic alopecia and alopecia areata. … Dr. Amiya Prasad


Scientists have identified a hair-loss protein in a development that could pave the way for a cure for male-pattern baldness.

By Donna Bowater – The Daily Telegraph

The discovery could mean treatments are developed to suppress the protein and to stop baldness, although it would not reverse the effects to reverse hair loss.

Tests were carried out on tissue from the scalps of more than 20 men with male pattern baldness, known as androgenic alopecia (AGA).

The results showed bald areas had levels of the protein PGD2 three times higher than hairy areas.

There are already 10 drugs available that can block the receptor that allowed PGD2 to work, which could help researchers develop a treatment in the form of a cream or ointment.

The research, led by Professor George Cotsarelis from the University of Pennsylvania, was published in the journal Science Translational Medicine.

“Our findings should lead directly to new treatments for the most common cause of hair loss in men, AGA,” the team said.

“The potential for developing these compounds into topical formulations for treating AGA should elicit great interest moving forward.”

Professor Cotsarelis added: “Although a different prostaglandin was known to increase hair growth, our findings were unexpected, as prostaglandins haven’t been thought about in relation to hair loss, yet it made sense that there was an inhibitor of hair growth, based on our earlier work looking at hair follicle stem cells.”

Future studies are expected to investigate whether a protein inhibitor could also help women with AGA.

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ACell results from Oslo, Norway

A study hair loss treatment was conducted in Oslo, Norway in August of 2011. The study was sponsored by Poseidon Clinic, one of the largest hair restoration practices in Europe. Among the patients treated with ACell plus PRP were men and women experiencing genetic hair loss. Injection therapy and hair transplant surgery was performed by Dr.Kosmidis Charalampos, under the supervision of the pioneering ACell treatment doctor under special permission of the Norway government.

Below are photos of a mid-fifties female experiencing diffuse female genetic alopecia, post menopause. She was treated with ACell plus PRP hair regrowth injection therapy, known as Hair Rescue. After photo was sent by Dr. Charalampos, 6 months after treatment. the patient had no hair transplant surgery. No other treatments were applied.

Female Hair Loss

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ACell + PRP Injections – Results by Dr. Niedbalski

Below is a before and after comparison of a patient of Dr. Robert Niedbalski* of Northwest Hair Restoration in Tacoma, WA. The patient had hair transplant surgery in the front and only ACell + PRP injections in the crown. Follow up is at 4 months. ACell/PRP injected into the entire crown *Note microscopic view of scalp hair density. (View enlarge images full screen)

Acell with PRP Therapy for Crown Area*Dr. Niebalski has been collaborating and using the same protocol co-developed by Dr. Prasad, which Dr. Niedbalski has credited with his success with ACell + PRP applications.

Donor Area Follow Up (Different patient) – 4 months post op Donor closure with ACell

Donor area healing

Donor area healing – 4 months post op. Note dark new hairs growing through previious strip scar. Photo courtesy of Dr. Robert Niedbalski

 

 

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ACell and Enhanced PRP Injection results treating Alopecia Areata

Severe Alopecia Aereata

Alopecia Areata is an Auto-immune disease that usually resolves itself with-in 6 months and in some cases responds to steroid injections. When there is no response by 6 months, the bald areas it creates is usually permanent. ACell/PRP with Hydr-ACell was employed in these “lost cases” to try to stimulate hair re-growth by Adult Stem Cell conversion. Early results seem promising as can be seen in the photo above.

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ACell (Matri-stem) Suspended in Arterial Blood Serum/PRP (Platelet Rich Plasma) to Retard Genetic/Other Types of Hair Loss and Possibly Re-grow Miniaturizing Scalp Hairs.

ACell and PRP injected into the scalp

ACell and PRP injected into the scalp prior to hair transplantation.

Much has been written as of late in the use of PRP (Platelet Rich Plasma) Injections to slow down or stop balding as well as to re-grow miniaturizing scalp hairs.  Much of the early reported variable successes (Greco1) have been attributed to the fact that there are significant vital proteins (Collagen IV etc.) as well as multiple growth factors (ie: VGRF) that are vital to terminal hairs along with hair survival and enhancement in general. It has been postulated (Greco1) that the addition of ECM (Extracellular matrix) may significantly improve the results.

We agree…

What Is ACell (Matristem)?

ACell is the by-product of urinary bladder tissue (which has remarkable regenerative properties). The product is stripped of all cells (ACell) as well as muscle tissue thereby preventing graft vs. host reactions (Allergic Reactions) when introduced in humans. The way it works (in wound healing) is by recruiting huge numbers

PRP

PRP Prepared and ready to mix with the Matristem

of Adult Stem Cells along with tremendous blood supply to the sight of a wound. It then effectively changes these inactive Adult Stem Cells back into Progenitor Cells (the Active Form) to direct healing by duplication of normal tissue rather than scar formation which is the only method normally available to humans for healing. What is important to understand is that when we are in-utero (mother’s womb), we develop by the direction of Embryonic Stem Cells. Upon birth these stem cells still remain in our  bloodstream, however they change to Adult Stem Cells which are inactive.

ACell also provides a multitude of growth factors and proteins necessary for tissue regeneration as well as a scaffold  on which to reconstruct the tissue. The scaffold is only temporary and soon disappears allowing the healing and regeneration to be carried out by one’s own cells and tissue.

Why ACell?

Matristem is unique in that it is Bi-Modal and contains a Basement Membrane necessary to attract and propagate both Epithelial and Endothelial Cells—necessary elements for duplication and restructuring of skin and hairs. Matristem works by setting up a temporary cellular scaffold or bridge and then by attracting massive blood supply plus Adult Stem Cells (there are large numbers of inactive adult stem cells circulating in all humans  after we are born) to the site of injury where they are converted back into Progenitor Cells.

Preparation of the PRP

Preparation of the PRP

ACell also contains more than ample amounts of the necessary Proteins and Growth Factors to reconstruct and copy tissue along with nerves and appendages (hair for example). Recently it has been shown that PRP (as well as, we suspect ,  the serum from spun down arterial blood) contain large numbers of Adult Stem Cells. By pre-mixing the ACell with either the Arterial Serum (or more easily the PRP in a non-surgical patient) we are skipping the step of waiting for the Adult Stem Cells to migrate to the injection sites and in essence pre-activating the injections. The injection sites serve as microwounds which ACell requires to begin the healing (duplication) process. In our opinion, wounds cannot be superficial, but rather, must be down to the  subcutaneous tissue level in order to maximize effectiveness.

Our future studies are focused on comparing side by side (in the same patient with thinning hair) the results of injections of PRP alone with PRP + Matristem. Early results in transplant patients (where it is easier to obtain Arterial blood from the surgical donor area) have shown that when Matristem plus spun down Arterial Blood Plasma are combined and then injected in thinning areas other than where the transplants are placed, there appears to be re-growth of these miniaturizing hairs. The results are still very early but make sense in light of previous reported (Greco1) PRP injection results. We postulate that there must also be some sort of  Competitive Inhibition with the Androgen Receptors or interruption in delivery by Messenger RNA for this to actually succeed. We are working with Harvest Technologies (PRP Specialists) to see where this will take us.

We are cautiously optimistic at this point.

1. Greco, J, Brandt, R. The effects of autologous platelet rich plasma and various growth factors on non-transplanted miniaturized hair. Hair Transplant Forum Int’l, Vol 19:2, 49-50, March /April 2009.

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